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J Biol. 2009 Aug 27;8(8):73. doi: 10.1186/jbiol165.

Insulators as mediators of intra- and inter-chromosomal interactions: a common evolutionary theme.

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  • 1Department of Biology, Emory University, 1510 Clifton Road NE, Atlanta, GA 30322, USA.

Abstract

Insulator elements mediate intra- and inter-chromosomal interactions. The insulator protein CCCTC-binding factor (CTCF) is important for insulator function in several animals but a report in BMC Molecular Biology shows that Caenorhabditis elegans, yeast and plants lack CTCF. Alternative proteins may have a similar function in these organisms.

PMID:
19725934
[PubMed - indexed for MEDLINE]
PMCID:
PMC2776911
Free PMC Article
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