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Am J Psychiatry. 2009 Oct;166(10):1118-23. doi: 10.1176/appi.ajp.2009.08101606. Epub 2009 Sep 1.

Clinical messages from the Treatment for Adolescents With Depression Study (TADS).

Author information

  • 1Division of Neurosciences Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA. john.march@duke.edu

Abstract

OBJECTIVE:

The purpose of this report was to summarize the key clinical messages from the Treatment for Adolescents with Depression Study (TADS).

METHODS:

TADS is a National Institute of Mental Health (NIMH)-funded randomized controlled trial designed to evaluate the relative effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), and the combination of fluoxetine plus CBT across acute treatment, maintenance treatment, and naturalistic follow-up periods among adolescents with major depressive disorder.

RESULTS:

Findings revealed that 6 to 9 months of combined fluoxetine plus CBT should be the modal treatment from a public health perspective as well as to maximize benefits and minimize harms for individual patients.

CONCLUSION:

The combination of fluoxetine and CBT appears to be superior to both CBT monotherapy and fluoxetine monotherapy as a treatment for moderate to severe major depressive disorder in adolescents.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT80006286.

[PubMed - indexed for MEDLINE]
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