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Menopause Int. 2009 Sep;15(3):107-12. doi: 10.1258/mi.2009.009028.

Nocturnal transcutaneous carbon dioxide tension in postmenopausal estrogen users and non-users.

Author information

  • 1Sleep Research Unit, Department of Physiology, University of Turku, Dentalia, Turku, Finland. jemato@utu.fi

Abstract

OBJECTIVE:

The effect of menopause on breathing is not fully understood. We have previously shown that postmenopausal women have a higher sleep-induced increase in transcutaneously measured carbon dioxide tension (TcCO(2)) than premenopausal women. Therefore, we hypothesized that estrogen therapy (ET) would normalize this sleep-induced TcCO(2) increase.

METHODS:

Nine postmenopausal ET users and nine non-users went through an overnight polygraphic sleep study including continuous monitoring of TcCO(2).

RESULTS:

TcCO(2) levels were higher during sleep than evening wakefulness (awake median 6.55 kPa versus sleep median 6.90 kPa, P = 0.001). ET users had a greater sleep-induced increase in TcCO(2) than non-users when comparing the difference between wakefulness and slow-wave sleep (0.85 kPa versus 0.28 kPa, P = 0.004). Lower sleep efficiency was associated with higher sleep-induced increase in TcCO(2).

CONCLUSIONS:

In contrast to our initial hypothesis, postmenopausal ET users have a higher sleep-induced increase in TcCO(2) than women without ET. Thus, TcCO(2) may be sensitive in measuring the peripheral estrogen effect. These findings warrant placebo-controlled intervention studies to confirm the effects of ET on TcCO(2) measurements.

PMID:
19723680
[PubMed - indexed for MEDLINE]
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