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Cell Metab. 2009 Sep;10(3):161-2. doi: 10.1016/j.cmet.2009.08.006.

Getting a "Hold" on NPC2.

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  • 1Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. dory@wustl.edu

Abstract

Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.

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PMID:
19723490
[PubMed - indexed for MEDLINE]
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