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Cell Metab. 2009 Sep;10(3):161-2. doi: 10.1016/j.cmet.2009.08.006.

Getting a "Hold" on NPC2.

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  • 1Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA. dory@wustl.edu


Lipoprotein cholesterol is mobilized from lysosomes by actions of the NPC1 and NPC2 proteins. In this issue of Cell Metabolism, Harrison et al. report on identification of an NPC2-interacting protein, the Nogo-B receptor, that regulates NPC2 protein levels. NPC2 stabilization may represent a novel mechanism through which cells respond to endocytosed cholesterol.

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