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Future Microbiol. 2009 Sep;4(7):779-82. doi: 10.2217/fmb.09.56.

Complete transcriptional profile of an environmental pathogen.

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  • 1Department of Microbiology & Immunology, University of Illinois at Chicago, Chicago, IL 60612-7344, USA. nfreitag@uic.edu


Evaluation of: Toledo-Arana A, Dussurget O, Nikitas G et al.: The Listeria transcriptional landscape from saprophytism to virulence. Nature 459 (7249), 950-956 (2009). Bacteria adapt to a variety of environmental conditions through changes in gene regulation and gene expression. Listeria monocytogenes is an environmental bacterium that exists as a saprophyte but is capable of transitioning into a pathogen upon ingestion by a susceptible host. In this report, Toledo-Arana et al. present the complete transcriptome of L. monocytogenes and identify a number of novel RNA regulatory elements that may facilitate bacterial adaptation to diverse environments. Their report illustrates a global coordination of transcriptional responses that takes place as the bacterium transitions from life in broth culture to life inside of an infected host.

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