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    J Neural Eng. 2009 Oct;6(5):55004. Epub 2009 Sep 1.

    Control of a brain-computer interface without spike sorting.

    Fraser GW, Chase SM, Whitford A, Schwartz AB.

    Department of Neurobiology, University of Pittsburgh, PA 15213, USA. gwf2@pitt.edu

    Two rhesus monkeys were trained to move a cursor using neural activity recorded with silicon arrays of 96 microelectrodes implanted in the primary motor cortex. We have developed a method to extract movement information from the recorded single and multi-unit activity in the absence of spike sorting. By setting a single threshold across all channels and fitting the resultant events with a spline tuning function, a control signal was extracted from this population using a Bayesian particle-filter extraction algorithm. The animals achieved high-quality control comparable to the performance of decoding schemes based on sorted spikes. Our results suggest that even the simplest signal processing is sufficient for high-quality neuroprosthetic control.

    PMID: 19721186 [PubMed - in process]

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