J Mol Cell Biol. 2009 Dec;1(2):64-5. Epub 2009 Aug 30.

When Shigella tells the cell to hang on.

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Inserm U971, Unité de Communications Intercellulaires et Infections Microbiennes, Collège de France, 11, Place Marcelin Berthelot, 75005 Paris Cedex, France.

Abstract

OspE, a Shigella type III effector binds to integrin-like kinase and enhances cell adhesion to better disseminate and colonize the intestinal epithelium. Because of the existence of OspE orthologues in other enteropathogens such as enteropathogenic Escherichia coli or Salmonella sp., maintenance of cell adhesion appears as a widespread strategy for bacteria that interact with the intestinal epithelium.

PMID:: 19720630; [PubMed - indexed for MEDLINE]

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When Shigella tells the cell to hang on.

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