A convenient ultrasound-promoted regioselective synthesis of fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines

Ultrason Sonochem. 2010 Feb;17(2):301-5. doi: 10.1016/j.ultsonch.2009.08.001. Epub 2009 Aug 7.

Abstract

Fused polycyclic 4-aryl-3-methyl-4,7-dihydro-1H-pyrazolo[3,4-b]pyridines were obtained in a three-component regioselective reaction of 5-amino-3-methyl-1H-pyrazole, 2H-indene-1,3-dione and arylaldehydes in ethanol under ultrasound irradiation. This rapid method produced the products in short reaction times (4-5min) and excellent yields (88-97%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemistry, Organic / methods
  • Chemistry, Pharmaceutical / methods
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry*
  • Pyridines / chemical synthesis
  • Pyridines / chemistry*
  • Spectrophotometry, Infrared
  • Ultrasonics*

Substances

  • 1H-pyrazolo(3,4-b)pyridine
  • Pyrazoles
  • Pyridines