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Indian J Urol. 2007 Jul;23(3):257-60. doi: 10.4103/0970-1591.33720.

Effect of Ruta graveolens and Cannabis sativa alcoholic extract on spermatogenesis in the adult wistar male rats.

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  • 1Department of Biology, Faculty of Sciences, Isfahan University, Isfahan, Iran.

Abstract

OBJECTIVE:

The present study was undertaken to evaluate the effects of alcohol extracts of Ruta graveolens and Cannabis sativa that were used traditionally in medieval Persian medicine as male contraceptive drugs, on spermatogenesis in the adult male rats.

MATERIALS AND METHODS:

Ethanol extracts of these plants were obtained by the maceration method. The male rats were injected intraperitionaly with C. sativa and R. graveolens 5% ethanol extracts at dose of 20 mg/day for 20 consecutive days, respectively. Twenty-four hours after the last treatment, testicular function was assessed by epididymal sperm count.

RESULT:

The statistical results showed that the ethanol extracts of these plants reduced the number of sperms significantly (P=0.00) in the treatment groups in comparison to the control group. The results also showed that the group, treated by extract of R. graveolens reduced spermatogenesis more than the group treated by extracts of C. sativa.

CONCLUSION:

The present study demonstrated the spermatogenesis reducing properties of the ethanol extracts of R. graveolens and C. sativa in the adult male wistar rats but more studies are necessary to reveal the mechanism of action that is involved in spermatogenesis.

KEYWORDS:

Cannabis sativa; Ruta graveolens; fertility-decreasing properties; spermatogenesis

PMID:
19718326
[PubMed]
PMCID:
PMC2721602
Free PMC Article

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