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N Engl J Med. 2009 Sep 17;361(12):1139-51. doi: 10.1056/NEJMoa0905561. Epub 2009 Aug 30.

Dabigatran versus warfarin in patients with atrial fibrillation.

Collaborators (1725)

Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Reilly PA, Themeles E, Varrone J, Wang S, Palmcrantz-Graf E, Haehl M, Wallentin L, Connolly SJ, Ezekowitz MD, Yusuf S, Oldgren J, Wallentin L, Alings AM, Amerena JV, Avezum A, Baumgartner I, Brugada J, Budaj A, Caicedo V, Ceremuzynski L, Chen JH, Commerford PJ, Dans AL, Darius H, Di Pasquale G, Diaz R, Erol C, Ferreira J, Flaker GC, Flather MD, Franzosi MG, Gamboa R, Golitsyn SP, Gonzalez Hermosillo JA, Halon D, Heidbuchel H, Hohnloser SH, Hori M, Huber K, Jansky P, Kamensky G, Keltai M, Kim S, Lau CP, Le Heuzey JY, Lewis BS, Liu LS, Nanas J, Razali O, Pais PS, Parkhomenko AN, Pedersen KE, Piegas LS, Raev D, Simmers TA, Smith PJ, Talajic M, Tan RS, Tanomsup S, Toivonen L, Vinereanu D, Xavier D, Zhu J, Diener HC, Joyner CD, Diehl A, Ford G, Robinson M, Silva J, Diener HC, Joyner CD, Diehl A, Ford G, Silva J, Sleight P, Wyse DG, Collier J, De Mets D, Hirsh J, Lesaffre E, Ryden L, Sandercock P, Anastasiou-Nana MI, Andersen G, Annex BH, Atra M, Avezum A, Bornstein NM, Boysen G, Brouwers PJ, Buerke M, Burrell LM, Chan YK, Chen WH, Cheung RT, Commerford PJ, Divakaramenon S, Donnan GA, Duray GZ, Dvorakova H, Eikelboom J, Fiedler J, Gardinale E, Gates PC, Goshev EG, Goto S, Gross B, Guimaraes HP, Gulkevych O, Haberl RL, Halon D, Hankey G, Hartikainen J, Healey J, Hohnloser SH, Iliesiu AM, Irkin O, Jansky P, Jaxa-Chamiec T, Jolly S, Kamensky G, Kaste KA, Keltai M, Kies B, Kostov KD, Kristensen KS, Labovitz AJ, Lassila RP, Lee KL, Lewis BS, Piegas LS, Lutay YM, Magloire P, Mak KH, Meijer A, Mihov L, Morillo CA, Morillo LE, Nair GM, Norrving B, Ntalianis A, Ntsekhe M, Olah L, Pasco PM, Peeters A, Perovic V, Petrov I, Pizzolato G, Rafti F, Rey NR, Ribas S, Rokoss M, Sarembock IJ, Sheth T, Shuaib A, Simmers TA, Sitkei E, Sorokin E, Srámek M, Strozynska E, Tanne D, Thijs VN, Tomek A, Turazza F, Vanhooren G, Vizel SA, Vos J, Wahlgren N, Weachter R, Zaborska B, Zaborski J, Zimlichman R, Cong J, Fendt K, Muldoon S, Reilly PA, Varrone J, Wang S, Bajkor S, Grinvalds A, Malvaso M, Pogue J, Robinson M, Simek K, Themeles E, Yang S, Alzogaray MF, Bono JO, Caccavo A, Cartasegna L, Casali WP, Cuello JL, Cuneo CA, Elizari MV, Fernandez AA, Ferrari AE, Gabito AJ, Goicoechea RF, Gorosito VM, Hirschson A, Hominal MA, Hrabar AD, Liberman A, Mackinnon IJ, Manzano RD, Muratore CA, Nemi SA, Rodriguez MA, Sanchez AS, Secchi J, Vogel DR, Amerena JV, Colquhoun DM, Crimmins DS, Dart AM, Davis SM, Hand PJ, Kubler PA, Lehman RG, McBain G, Morrison HC, New G, Singh BB, Spence CZ, Waites JH, Auer J, Doweik L, Freihoff F, Gaul G, Gazo F, Geiger H, Giacomini G, Huber GW, Huber K, Jukic I, Lamm G, Niessner H, Podczeck A, Schuh J, Siostrzonek P, Steger C, Vogel B, Watzak R, Weber HS, Weihs W, Blankoff I, Boland JL, Brike C, Carlier M, Cools F, de Meester A, De Raedt HJ, De Wolf L, Dhooghe GM, Dilling-Boer D, Elshot SR, Fasseaux S, Goethals M, Goethals P, Gurne O, Heidbuchel H, Hellemans S, Ivan B, Jottrand M, Kersschot I, Lecoq E, Marcovitch O, Melon D, Miljoen H, Missault L, Pierard LA, Provenier F, Rousseau MF, Stockman D, Tran-Ngoc E, van Mieghem W, Vandekerckhove Y, Vandervoort P, Verrostte J, Vijgen J, Armaganijan D, Braga C, Braga JC, Cipullo R, Cunha CL, de Paola A, Delmonaco MI, Guimaraes FV, Herek L, Kerr Saraiva JF, Maia LN, Lorga AM, Lorga-Filho AM, Marino RL, Melo CS, Mouco OM, Pereira VC, Precoma DB, Rabelo W, Rassi S, Rossi PR, Rossi Neto JM, Silva FM, Vidotti MH, Zimmermann SL, Anev ED, Balabanov TA, Baldjiev ES, Bogusheva ES, Chaneva MA, Filibev IG, Gotcheva NN, Goudev AR, Gruev IT, Guenova DT, Kamenova ZA, Manov EI, Panov IA, Parvanova ZI, Pehlivanova MB, Penchev PT, Penkov NY, Radoslavov AL, Raev D, Ramshev KN, Runev NM, Sindzhielieva MN, Spirova DA, Tsanova VM, Tzekova ML, Yaramov GK, Aggarwal R, Bakbak AI, Bayly K, Berlingieri JC, Blackburn K, Bobbie C, Booth AW, Borts D, Bose S, Boucher P, Brown K, Burstein JM, Butt JC, Carlson BD, Chetty R, Chiasson JD, Constance C, Costi P, Coutu B, Deneufbourg I, Dion D, Dorian P, Douketis JD, Eikelboom J, Farukh S, Filipchuk NG, Fox BA, Fox HI, Gailey CB, Gauthier M, Glanz A, Green MS, Habot J, Hink H, Jolly S, Kearon C, Kouz S, Lai C, Lai K, Lalani AV, Lam AS, Lapointe LA, Leather RA, Ma PT, MacKay E, Mangat I, Mansour S, Melton E, Mitchell LB, Morillo CA, Morris AL, Nair GM, Nisker WA, O'Donnell MJ, O'Hara G, Omichinski LM, Pandey AS, Parkash R, Pesant Y, Pilon C, Pistawka KJ, Powell CN, Price JB, Prieur S, Rebane TM, Ricci AJ, Roberge J, Roy M, Sapp JL, Savard D, Schulman S, Sehl MJ, Sestier F, Shandera R, Shu D, Sterns LD, St-Hilaire R, Syan GS, Talajic M, Talbot P, Teitelbaum I, Tytus RH, Vizel SA, Winkler L, Zadra R, Zidel BS, Bai XJ, Gao W, Gao X, Guan DM, He ZS, Hua Q, Li H, Li L, Li WM, Lu GP, Lv S, Meng K, Niu HY, Qi DG, Qi SY, Qian F, Sun NL, Wang HY, Wang NF, Yang YM, Zeng H, Zhang F, Zhang FR, Zhang L, Bohorquez R, Rosas JF, Saent L, Vacca M, Velasco VM, Belohlavek J, Cernohous M, Choura M, Dedek V, Filipensky B, Hemzsky L, Jansky P, Karel I, Kopeckova I, Kovarova K, Labrova R, Madr T, Poklopova Z, Rucka D, Simon J, Skalicka H, Smidova M, Spinar J, Dodt KK, Egstrup K, Friberg J, Haar D, Husted S, Jensen GV, Joensen AM, Klarlund KK, Lind Rasmussen S, Melchior TM, Olsen ME, Pedersen KE, Poulsen MK, Ralfkiaer N, Rasmussen LH, Skagen K, Airaksinen KE, Huikuri HV, Hussi EJ, Kettunen P, Mänttäri M, Melin JH, Mikkelsson J, Peuhkurinen K, Toivonen L, Virtanen VK, Ylitalo A, Agraou B, Boucher L, Bouvier JM, Boye A, Boye B, Decoulx EM, Defaye P, Delay M, Desrues H, Gacem K, Igigabel P, Jacon P, Le Heuzey JY, Leparree S, Magnani C, Martelet M, Movallem J, Olive T, Poulard JE, Tiam B, Appel KF, Appel S, Bansemir L, Borggrefe M, Brachmann J, Bulut-Streich N, Busch K, Darius H, Dempfle CE, Desaga M, Desaga V, Dormann A, Duray GZ, Fechner I, Genth-Zotz S, Haberbosch WG, Harenberg J, Haverkamp WL, Henzgen R, Heuer H, Hohnloser SH, Horacek T, Huttner HB, Janssens U, Jantke HJ, Klauss V, Koudonas D, Kreuzer J, Kuckuck H, Maselli A, Müegge A, Munzel TF, Nitsche K, Nledegjen A, Parwani A, Pluemer-Schmidt M, Pollock BW, Salbach BI, Salbach PB, Schaufele T, Schoels W, Schwab S, Siegmund U, Veltkamp R, Von Hodenberg E, Weber R, Zechmeister M, Anastasiou-Nana MI, Anastasopoulous AA, Foulidis VO, Kaldara E, Karamitsos K, Karantzis J, Kirpizidis H, Kokkinakis C, Krommydas A, Lappas C, Lappas GI, Manolis A, Manolis AS, Orfanidis Z, Papamichalis M, Peltekis L, Savvas S, Skoumpourdis EA, Stakos DA, Styliadis I, Triposkiadis F, Tsounis D, Tziakas DN, Zafiridis T, Zarifis JH, Chan GC, Chan WK, Chan WS, Lau CL, Tse HF, Tsui PT, Yu CM, Yue CS, Fugedi K, Garai B, Jánosi A, Kadar A, Karpati P, Keltai K, Kosa I, Kovacs I, Laszlo Z, Mezei L, Rapi J, Regos LI, Sitkei E, Szakal I, Szigyarto I, Toth K, Zsa'ry A, Agarwal DK, Aggarwal RK, Arulvenkatesh R, Bharani A, Bhuvaneswaran JS, Byrapaneni RB, Chandwani P, Chopra S, Desai N, Deshpande V, Golla NP, Gupta JB, Haridas KK, Hiremath J, Jain AS, Jain M, Jhala DA, Joseph J, Kaila M, Kannaiyan A, Kumar S, Kuruvila P, Mahorkar VK, Metha A, Naik AM, Narayanan S, Pais PS, Panwar RB, Reddy C, Sawhney JP, Shah SM, Sharma S, Shetty GS, Sinha N, Sontakke NN, Srinivas A, Trivedi MR, Vadagenalli PS, Vijayakumar M, Ben-Aharon Y, Benhorin J, Bogomolny N, Bornstein NM, Botwin-Shimko S, Bova I, Brenner B, Burstein M, Butnaru A, Caspi A, Danenberg HD, Dayan M, Eldar M, Elian D, Elias M, Elis A, Esanu G, Genin I, Goldstein LH, Grossman E, Hamoud S, Hayek T, Ilani N, Ilia R, Klainman EI, Leibowitz A, Leibowitz D, Levin I, Lishner M, Lotan C, Mahagney A, Marmor A, Motro M, Peres D, Plaev T, Reisen LH, Rogowski O, Schwammenthal E, Schwammenthal Y, Shechter M, Shochat M, Shotan A, Strasberg B, Sucher E, Tanne D, Telman G, Turgeman Y, Tzoran I, Weiss AT, Weitsman T, Weller B, Wexler DH, Wolff R, Yarnitsky D, Zeltser D, Zimlichman R, Argiolas G, Arteni F, Barbiero M, Bazzucco R, Bernardi D, Bianconi L, Bicego D, Brandini R, Bresciani B, Busoni F, Carbonieri E, Carini M, Catalano A, Cavallini C, D'Angelo G, De Caterina R, Di Niro M, Di Pasquale G, Filigheddu F, Fraticelli A, Marconi R, Mennuni M, Moretti L, Mos L, Pancaldi LG, Pirelli S, Renda G, Santini M, Tavarozzi I, Terrosu P, Uneddu F, Viccione M, Zanini R, Zingarini G, Aoyagi T, Eguma H, Fujii K, Fukuchi M, Fukunami M, Furukawa Y, Furuya J, Haneda K, Hara S, Hiroe M, Iesaka Y, Iijima T, Ishibashi Y, Iwade K, Kajiya T, Kakinoki S, Kamakura S, Katayama Y, Kihara Y, Kimura K, Kobayashi S, Kono K, Koretsune Y, Marui N, Matsuyama T, Meno H, Miyamoto N, Morikawa S, Myojin K, Nakamura T, Nishi Y, Ogawa T, Onaka H, Sakakibara T, Sakurai S, Sasaki Y, Sato H, Sugii M, Sumii K, Suzuki S, Takagi M, Takenaka T, Takeuchi K, Tanaka S, Tanouchi J, Ueda K, Ueyama Y, Ujihira T, Usui M, Yagi M, Yamada T, Yamamoto H, Yokochi M, Zen E, Abd Ghaphar AK, Ang CK, Chee KH, Fong AF, Ismail O, Jeyaindran S, Kaur S, Lee TC, Razali O, Sandhu RS, Shah RP, Suganthi S, Zainal Abidin S, Alvarado-Ruiz R, Carrillo J, Delgado E, Fernandez Bonetti PA, Gonzalez Hermosillo JA, Leiva JL, Meaney A, Olvera R, Olvera R Jr, Peralta-Heredia R, Rodriguez I, Ruiz Rabasa CM, Solache G, Villeda Espinosa E, Ahmed S, Alings AM, Badings E, Bartels GL, Beganovic M, Bruning TA, Ciampricotti R, Cozijnsen L, Crijns HJ, Daniels MC, de Waard DE, den Hartog FR, Dirkali A, Groenemeijer BE, Heesen WF, Heijmeriks JA, Hoogslag PA, Huizenga A, Idzerda HH, Kragten JA, Krasznai K, Lenderink T, Liem AH, Linssen GC, Lok DJ, Meeder JG, Michels HR, Plomp J, Pos L, Posma JL, Postema PG, Salomonsz R, Simmers TA, Stoel I, Tans JG, Thijssen HJ, Timmermans AJ, Tteleman RG, van Bergen PF, van de Klippe HA, van der Zwaan C, van Eck JW, van Es AJ, van Gelder IC, van Kempen LH, van Kesteren HA, van Rossum P, Veldmeyer S, Wilde AA, Arnesen H, Atar D, Breder O, Istad H, Radunovic Z, Rykke DE, Sirnes PA, Smith PJ, Tveit A, Ulimoen SR, Cabrera W, Duenas R, Gamboa R, Heredia JM, Horna ME, Hurtado Y, Salazar PM, Abola MT, Anonuevo JC, Arellano RS, Dioquino C, Morales DD, Reyes EB, Rogelio GG, Roxas AA Jr, Sulit DJ, Bacior B, Dulak E, Gniot J, Goncikowski J, Grodecki J, Kalarus ZF, Kawecka-Jaszcz K, Miekus P, Monies F, Piepiorka M, Pilichowska E, Plizio E, Rekosz J, Rybicka-Musialik A, Streb WA, Styczkiewicz M, Szpajer M, Trusz-Gluza M, Wasilewska-Piepiorka A, Zaborska B, Adragao P, Branco V, Canhão P, Cunha L, Falcão F, Lopes G, Machado C, Martinez-Marcos J, Monteiro PF, Parreira L, Pinto AN, Providencia LA, Salgado AV, Santos JF, Timoteo AT, Capalneanu R, Cinteza M, Margulescu AD, Turdeanu DS, Vinereanu D, Vintila VD, Baranov VL, Berngardt ER, Dzhordzhikiya TR, Golitsyn SP, Gordeev IG, Grigoryev YV, Isaeva MU, Ivleva AY, Kokorin VA, Komarov AL, Maximenko OK, Maykov EB, Novikova N, Novikova TN, Panchenko EP, Poltavskaya MG, Popova YN, Pronina SA, Revishvili ASh, Shlyakhto EV, Shustov SB, Sidorenko BA, Sinopalnikov AI, Sulimov V, Syrkin AL, Titkov AY, Titkov YS, Zateyshchikov DA, Zavaritskaya OP, Chia PL, Foo D, Sim KL, Tan RS, Bugan V, Buganova I, Dúbrava J, Kaliska G, Kamensky G, Masarovicova M, Mikes P, Mikes Z, Murin J, Pella D, Rybar R, Sedlák J, Skamla M, Spurný P, Strbova J, Uhliar R, Commerford PJ, Disler LJ, Engelbrecht JM, Jankelow D, King J, Klug EQ, Munnick M, Okreglicki AM, Routier RJ, Snyders FA, Theron HD, Wittmer H, Cha TJ, Cho JG, Choi IS, Choi JI, Choi KJ, Han KR, Heo JH, Jang SW, Kang TS, Kim HS, Kim KS, Kim SJ, Kim SS, Kim YH, Kim YN, Lee MH, Lee MY, Nam GB, Oh DJ, Park HW, Park JS, Rho TH, Shin DG, Shin EK, Alonso JJ, Cano L, Castellano NP, Criado-Millan AJ, Curcio A, Egea P, Escudier JM, Grande A, Grande JM, Gusi-Tragant G, Lozano IF, Martin AM, Martinez-Rubio A, Mont L, Perez-Villacastin J, Sosa L, Ali M, Andersson T, Bandh S, Blomstrom Lundqvist CM, Cherfan P, Fengsrud E, Fluur C, Herlitz J, Hijazi Z, Hoglund N, Hojeberg B, Jabro J, Juhlin T, Kjellman B, Lonnberg I, Maru F, Morlid L, Nilsson OR, Oldgren J, Ronn F, Rosenqvist M, Walfridsson H, Baumgartner I, Engelter ST, Gallino A, Lyrer PA, Moccetti T, Petrova I, Chang YJ, Chen CH, Chen JH, Chen MY, Cheng JJ, Chiang TR, Chung WT, Hsia CH, Hsu CY, Hu HH, Jeng JS, Lai WT, Lien LM, Lin KH, Liu CH, Lo HS, Peng GS, Po HL, Ryu SJ, Tsai CD, Tsai LM, Tseng CD, Wang JH, Wang SF, Yang SP, Kiatchoosakun S, Krittayaphong R, Kuanprasert S, Ngarmukos T, Simtharakaew T, Sukanandachai B, Sukonthasam A, Suwanagool A, Tanomsup S, Tatsanavivat P, Atmaca Y, Baris N, Boyaci B, Demir M, Erol C, Guneri S, Usal A, Yalcin R, Amosova KM, Beregova OP, Besaga YE, Ikorkin MR, Karapetyan K, Karpenko OI, Kononenko L, Kuryata O, Martynova L, Motylevska T, Okhryamkina O, Parkhomenko AN, Pavlyk SS, Perepelytsya MV, Rudenko LV, Skarzhevsky OA, Tkachenko LA, Tseluyko V, Usan N, Voronkov LG, Yshchenko KV, Zharinov OJ, Bryson VG, Butler R, Cargill RI, Chahal NS, Cleland JG, Cohen AT, Cruddas EM, Davey P, Davies J, Flather MD, Ford SL, Griffith K, Haynes R, Hill S, Javed M, Kadr HH, Lip GH, Machin J, McEneaney DJ, McInnes GT, McNeill AJ, Moriarty AJ, Muir S, O'Callaghan J, Purvis JA, Pye M, Senior R, Sutton DA, Thomas SH, Wilkinson PR, Wilmott R, Wrigley MJ, Abadier R, Abbud ZA, Adams KV, Adler SW, Agarwal S, Ahmed AM, Ahmed IS, Aiuto MA, Albrittun TD, Aliyar P, Allan JJ, Allen DP, Allen SL, Altschuller A, Amin M, Anand IS, Antolick AB, Arora R, Arouni AJ, Arslanian CL, Asinger RW, Aycock GR, Bariciano RJ, Baron SB, Barr MA, Bartkowiak AJ Jr, Baruch L, Basignani C, Bass ML, Bean B, Bedwell NW, Belber AD, Belew K, Bell YC, Bellinger RL, Bennett WT, Bensimhon DR, Benton R, Benton RE, Ben-Yehuda O, Bertolet BD, Betkowski AS, Bilazarian SD, Bissette JK, Bobade MB, Bolster DE, Bomba J, Book DM, Boscia JA, Bouchard A, Bowman LM, Bradley AJ 3rd, Brandt HD, Bricker CR, Brobyn TL, Brock RI, Broderick TM, Broedlin K, Brown AM, Browne KF, Burke SW, Burton ME, Buser GA, Capasso MK, Caplan WE, Cappelli J, Cardona C, Cardona F, Carlson T, Carr KW, Casey T, Cashion WR, Cass DT, Chandrashekar YS, Changlani M, Chapla PG, Chappell JH, Chen C, Chen Y, Cho NR, Cieszkowski JH, Clark DM, Clayton R, Clogston CW, Cockrell DJ, Cohen AI, Cohen TJ, Cole JF, Conway G, Cook VR, Cornish AL, Cossu SF, Costello DL, Courtade DJ, Covelli HC, Crenshaw BS, Crews LA, Crossley GH, Culp SC, Curtis BM, Darrow K, De Raad RE, DeGregorio M, DelNegro AA, Denny DM, Desai VS, Deumite NJ, Dewey L, Dharawat RN, Dobbs B, Donahue SM, Downey B, Downing J, Drehobl MA, Drewes WA, Drucker MN, Duff R, Duggal M, Dunlap SH, Dunning DW, DuThinh V, Dykstra GT, East C, Eblaghie MC, Edelstein J, Edmiston WA, Eisen HJ, Eisenberg SJ, Ellis JR, Ellison HS, Ellsworth S, Elshahawy M, Emlein G, Entcheva M, Essandoh LK, Estrada AQ, Ewing B, Ezekowitz MD, Faillace RT, Fanelli A, Farrell PW, Farris SW, Fattal PG, Feigenblum DY, Feldman GJ, Fialkow JA, Fiddler KM, Fields RH, Finkel MS, Finn C, Fischell TA, Fishbach M, Fishbein GJ, Fisher MM, Flaker GC, Fleischhauer FJ, Folk TG, Folkerth SD, Fortman RR, Frais MA, Friedman DC, Fuchs G, Fuller F, Garibian G, Gee FH, Gelernt MD, Genovely HC, Gerber JR, Germano JJ, Giardina JJ, Gilbert JM, Gillespie EL, Gilman EM, Gitler B, Givens DH, Glover R, Gogia HS, Gohn DC, Goldberg RK, Goldberger JJ, Goldscher DA, Goldstein M, Goraya T, Gordon DF, Gottlieb D, Grafner HL, Graham M, Graves MW, Graziano M, Greco SN, Greenberg ML, Greenspon AJ, Greer GS, Griffin DD, Grogan EW, Groo VL, Guarnieri T, Gupta A, Gupta J, Hack TC, Hall B, Hallak O, Halpern SW, Hamburg C, Hamroff GS, Han J, Handel F, Hankins SR, Hanovich GD, Hanrahan JA, Haque IU, Hargrove JL, Harnick PE, Harris JL, Hartley PA, Haskel EJ, Hatch D, Haught WH, Hearne S, Hearne SE, Hemphill JA, Henderson DA, Henes CH, Hengerer-Yates T, Hermany PR, Herzog WR, Hickey K, Hilton TC, Hockstad ES, Hodnett P, Hoffmeister R, Holland J, Hollenweger L, Honan MB, Hoopes DA, Hordes AR, Hotchkiss DA, Howard MA, Howard VN, Hulyalkar AR, Hurst P, Hutchison LC, Ingram J, Isakov T, Ison RK, Israel CN, Jackson BK, Jackson KN, Jacobson AK, Jain S, Jarmukli NF, Joffe I, Johnson LE, Johnson SA, Johnson SL, Jones AA, Joyce DB, Judson PL, Juk SS Jr, Kaatz S, Kaddaha RM, Kaplan KJ, Karunaratne HB, Kennett JD, Kenton DM, Kettunen JA, Khan MA, Khant RN, Kim SS, Kirkwood MD, Knight BP, Knight PO, Knutson TJ, Kobayashi JF, Kogan A, Kogan AD, Koren MJ, Kosinski EJ, Kosolcharoen P, Kostis JB, Kramer JH, Kramer SD, Kron J, Kuchenrither CR, Kulback SJ, Kumar A, Kushner D, Kutscher A, Labovitz AJ, Lai CK, Lam JB, Landau C, Landzberg JS, Lang DT, Lang JM, Lanzarotti CJ, Lascewski DL, Lau TK, Lee JK, Lee S, Leimbach WN, LePine AM, Lesser MF, Leuchak SH, Levy RM, Lewis WR, Lincoln TL, Lingerfelt WM, Liston M, Liu ZG, Lloret RL, Lohrbauer L, Longoria DC, Lott BM, Louder DR, Loukinen KL, Lovell J, Lue S, Mackall JA, Maletz L, Marlow L, Martin RC, Matsumura M, McCartney MJ, McDuffie D, McGough MF, McGrew FA 3rd, McGuinn WP, McMillen MD, McNeff J, McPherson CA, Meengs ME, Meengs WL, Meholick AW, Meisner JS, Melucci MB, Mercando A, Merlino JD, Meymandi SK, Miele MB, Miller RH, Miller SH, Minor ST, Mitchell MR, Modi M, Mody FV, Moeller CL, Moloney JF, Moran JE, Morcos NC, Morgan A, Mukherjee SK, Mullinax K, Murphy AL, Mustin AJ, Myers GI, Naccarelli GV, Nadar VK, Nallasivan M, Navas JP, Niazi IK, Nsah EN, Nunamaker JL, Ochalek TB, O'Dea DJ, Ogilvie PD, Olliff B, Omalley AK, O'Neill PG, Onufer JR, Orchard RC, Orihuela LA, Ortiz EC, O'Sullivan MT, Padanilam BJ, Pandey P, Parekh A, Patel DV, Patel RJ, Patel VB, Patlola RR, Pennock GD, Perlman R, Peters PH Jr, Petrillo AV, Pezzella S, Phillips D, Pierre-Louis JR, Pilcher G Jr, Pillai C, Pollock SG, Pond MS, Porterfield JK, Presant L, Pressler J, Pribble AH, Promisloff SD, Pudi KK, Putnam DL, Quartner J, Quinn JC, Quinnell CM, Raad GL, Rasmussen LA, Ray C, Reiffel JA, Reynertson S, Richardson JW, Riley CP, Rippy JS, Rittelmeyer JT, Roberts DM, Robertson R, Robinson VJ, Rocco TA Jr, Rosenbaum D, Roth EM, Rottman JN, Rough RR, Rubenstein JJ, Sakkal AM, Saleem T, Salerno DM, Samendinger ML, Sandeno S, Santilli TM, Santucci P, Sattar P, Saxman KA, Schaefer S, Schmidt J, Schneider RM, Schocken DD, Schrader MK, Schramm BA, Schultz RW, Schussheim AE, Schwarz EF, Seamon MC, Sestero JD, Shah MP, Shah R, Shalaby A, Shanes JG, Sheftel GL, Sheikh KH, Shein AB, Shemonsky NK, Shepler A, Sheridan E, Shipwash TM, Shopnick RI, Short WG, Shoukfeh MF, Sibia RS, Siler TM, Silva JA, Simons GR, Simpson AG, Simpson HR, Simpson VJ, Singh BN, Singh N, Singh VN, Sitz CJ, Skatrud L, Sklar J, Slotwiner DJ, Smith PF, Smith PN, Smith RH, Smith JE 3rd, Sodowick BC, Solomon AJ, Soltero EA, Sonel AF, Sperling R, Spiller C, Spink BZ, Sprinkle LW, Spyropoulos AC, Stamos TD, Steljes AD, Stillabower ME, Stover T, Strain JE, Strickland TL, Suresh DP, Takata TS, Taylor JS, Taylor M, Teague SM, Teixeia JM, Telfer EA, Terry PS, Terry RW, Thai HM, Thalin M, Thomas VN, Thompson CA, Thompson MA, Thornton JW, Tidman RE, Toler BS, Traina MI, Trippi JA, Ujiiye DL, Usedom JE, Van de Graaff E, Van de Wall LR, Vaughn JW, Ver Steeg D, Vicari RM, Vijay N, Vitale CB, Vlastaris AG, Voda J, Vora KN, Voyles WF, Vranian RB, Vrooman PS, Waack P, Waldo AL, Walker JL, Wallace MA, Walsh EA, Walsh RL, Walton A, Washam M, Wehner PS, Wei JY, Weiner S, Weiss RJ, Wells DM, Wera-Archakul W, Wertheimer JH, West SA, Whitaker JH, White ML, White RH, Whitehill JN, Wiegman PJ, Wiesel J, Williams J, Williams LE, Williams ML, Williamson VK, Wilson VE, Wilson WW, Woodfield SL, Wulff CW, Yates SW, Yousuf KA, Zakhary BG, Zambrano R, Zimetbaum P, Zoble R, Zopo AR, Zwerner PL.

Author information

  • 1Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada. connostu@phri.ca

Erratum in

  • N Engl J Med. 2010 Nov 4;363(19):1877.

Abstract

BACKGROUND:

Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor.

METHODS:

In this noninferiority trial, we randomly assigned 18,113 patients who had atrial fibrillation and a risk of stroke to receive, in a blinded fashion, fixed doses of dabigatran--110 mg or 150 mg twice daily--or, in an unblinded fashion, adjusted-dose warfarin. The median duration of the follow-up period was 2.0 years. The primary outcome was stroke or systemic embolism.

RESULTS:

Rates of the primary outcome were 1.69% per year in the warfarin group, as compared with 1.53% per year in the group that received 110 mg of dabigatran (relative risk with dabigatran, 0.91; 95% confidence interval [CI], 0.74 to 1.11; P<0.001 for noninferiority) and 1.11% per year in the group that received 150 mg of dabigatran (relative risk, 0.66; 95% CI, 0.53 to 0.82; P<0.001 for superiority). The rate of major bleeding was 3.36% per year in the warfarin group, as compared with 2.71% per year in the group receiving 110 mg of dabigatran (P=0.003) and 3.11% per year in the group receiving 150 mg of dabigatran (P=0.31). The rate of hemorrhagic stroke was 0.38% per year in the warfarin group, as compared with 0.12% per year with 110 mg of dabigatran (P<0.001) and 0.10% per year with 150 mg of dabigatran (P<0.001). The mortality rate was 4.13% per year in the warfarin group, as compared with 3.75% per year with 110 mg of dabigatran (P=0.13) and 3.64% per year with 150 mg of dabigatran (P=0.051).

CONCLUSIONS:

In patients with atrial fibrillation, dabigatran given at a dose of 110 mg was associated with rates of stroke and systemic embolism that were similar to those associated with warfarin, as well as lower rates of major hemorrhage. Dabigatran administered at a dose of 150 mg, as compared with warfarin, was associated with lower rates of stroke and systemic embolism but similar rates of major hemorrhage. (ClinicalTrials.gov number, NCT00262600.)

2009 Massachusetts Medical Society

Comment in

PMID:
19717844
[PubMed - indexed for MEDLINE]
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