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    Bioorg Med Chem Lett. 2009 Oct 1;19(19):5556-9. Epub 2009 Aug 15.

    Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.

    Ha do T, Tuan DT, Thu NB, Nhiem NX, Ngoc TM, Yim N, Bae K.

    Source

    College of Pharmacy, Chungnam National University, Daejeon 305-764, Republic of Korea.

    Abstract

    Moutan Cortex is a well-known herb in traditional Korean, Chinese, and Japanese anti-diabetic formulae. In the current study, we investigated the metabolic effects of isolated triterpenes (1-7) in HepG2 cells under high glucose conditions. These compounds remakably stimulated AMP-activated protein kinase (AMPK), GSK-3beta, and ACC phosphorylation. The compounds also increased glucose uptake and enhanced glycogen synthesis. Among these, compound 1 displayed the greatest potential anti-diabetic activity though the AMPK activation pathway. Compound 1 significantly increased the levels of phospho-AMPK, phospho-ACC, and phospho-GSK-3beta and stimulated glucose uptake and glycogen synthesis in a dose-dependent manner. In conclusion, our results suggest that these compounds, especially compound 1, may have beneficial roles in glucose metabolism via the AMPK pathway.

    PMID:
    19716700
    [PubMed - indexed for MEDLINE]

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