Send to:

Choose Destination
See comment in PubMed Commons below
J Neurol Sci. 2009 Dec 15;287(1-2):275-7. doi: 10.1016/j.jns.2009.08.004. Epub 2009 Aug 28.

Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis.

Author information

  • 1Department of Neurology, Okayama Kyokuto Hospital, Okayama 703-8265, Japan.


Limbic encephalitis is a rare central nervous system (CNS) manifestation of relapsing polychondritis (RP). Vasculitis is assumed to be the cause of CNS involvement in RP. Several studies, however, have described CNS involvement in RP with no evidence of vasculitis but with a more nonspecific inflammatory picture. We report a patient with limbic encephalitis associated with RP who presented with anti-glutamate receptor (GluR) epsilon2 (NR2B) autoantibodies in his cerebrospinal fluid and sera. Brain MRI showed a high signal intensity lesion in the medial temporal lobe and progressive atrophy without multifocal abnormality on fluid-attenuated inversion recovery scanning. Our patient's results raise the interesting possibility that anti-GluRepsilon2 (NR2B) antibodies function in the development of limbic encephalitis in certain patients with RP.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk