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Otolaryngol Head Neck Surg. 2009 Sep;141(3):358-63. doi: 10.1016/j.otohns.2009.05.034.

Outcomes of sinus surgery in adults with cystic fibrosis.

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  • 1Division of Rhinology and Sinus Surgery, Oregon Sinus Center, Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon 97239, USA.



Adults with cystic fibrosis (CF) represent a challenging subset of patients with chronic rhinosinusitis (CRS). While data suggest that endoscopic sinus surgery (ESS) may benefit pediatric CF patients, there remains a paucity of data regarding the impact of endoscopic sinus surgery on adult CF patients with CRS. Our purpose was to evaluate objective and quality-of-life measures in adult CF patients with CRS following ESS.


Nested case-control study.


Tertiary care center.


Twenty patients with CF were evaluated and matched to 20 controls without concomitant CF. Preoperative CT and preoperative/postoperative endoscopic findings were recorded as objective measures. Changes in two disease-specific quality-of-life (QoL) instruments were also evaluated both preoperatively and postoperatively.


Mean postoperative follow-up was similar for cases and controls (13.1 +/- 7.9 months vs 14.0 +/- 6.0 months, respectively). Preoperative CT scores (16.9 +/- 4.5 vs 10.9 +/- 5.9, P = 0.001) and endoscopy scores (9.3 +/- 5.8 vs 5.7 +/- 4.6, P = 0.049) were significantly worse in CF patients. Postoperative endoscopy scores were significantly worse for CRS patients with CF (P = 0.001), although the degree of improvement on endoscopy within each group was no different (P = 0.071). Additionally, both groups experienced similar improvement in QoL after ESS (all P > or = 0.134).


While baseline measures of disease severity are worse in the CF population, our data support objective and QoL improvements for adult patients with comorbid CF comparable to patients without CF.

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