Nat Genet. 2009 Sep;41(9):960-1.

An uphill battle toward pluripotency.

Abstract

The discovery that a cocktail of transcription factors can reprogram somatic cells into induced pluripotent stem (iPS) cells keeps revealing new secrets of cell fate specification. A new study with hematopoietic cells shows that progenitor cells are far more susceptible than differentiated cells to reprogramming.

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Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. [Nat Genet. 2009]
Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.
Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K. Nat Genet. 2009 Sep; 41(9):968-76. Epub 2009 Aug 9.
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. [Nature. 2009]
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Review Expression and activation of the reprogramming transcription factors. [Biochem Biophys Res Commun. 2009]
Review Expression and activation of the reprogramming transcription factors.
Guo J, Li ZC, Feng YH. Biochem Biophys Res Commun. 2009 Dec 25; 390(4):1081-6. Epub 2009 Nov 11.
Review Forcing cells to change lineages. [Nature. 2009]
Review Forcing cells to change lineages.
Graf T, Enver T. Nature. 2009 Dec 3; 462(7273):587-94.

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An uphill battle toward pluripotency.
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An uphill battle toward pluripotency.

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