Hum Genet. 1990 May;84(6):568-70.

Genetic polymorphisms of gene conversion within the duplicated human alpha-globin loci.

Nakashima H, Fujiyama A, Kagiyama S, Imamura T.

Source

Department of Human Genetics, National Institute of Genetics, Mishima, Japan.

Abstract

Of the 645 Japanese subjects studied, we have identified 10 individuals heterozygous for a chromosome with the triplicated alpha-globin loci. The frequency of the triple alpha-loci was 0.008 in this population, while that of the single alpha-locus, i.e., alpha-thalassemia 2 gene, might be lower than 0.0008. Analysis of haplotypes using particular RsaI site polymorphism in the alpha-globin gene complex strongly suggests that the triple alpha loci may have had multiple origins in this population.

PMID:: 1970975; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Globins

LinkOut - more resources

Full Text Sources

EBSCO

Medical

Supplemental Content

Save items

Related citations in PubMed

Gene conversions in the horse alpha-globin gene complex. [Mol Biol Evol. 1987]
Gene conversions in the horse alpha-globin gene complex.
Clegg JB. Mol Biol Evol. 1987 Sep; 4(5):492-503.
A family with segregating triplicated alpha globin loci and beta thalassemia. [Blood. 1983]
A family with segregating triplicated alpha globin loci and beta thalassemia.
Galanello R, Ruggeri R, Paglietti E, Addis M, Melis MA, Cao A. Blood. 1983 Nov; 62(5):1035-40.
Heterogeneity of the gamma-globin gene sequences in Japanese individuals: implication of gene conversion in generation of polymorphisms. [J Biochem. 1989]
Heterogeneity of the gamma-globin gene sequences in Japanese individuals: implication of gene conversion in generation of polymorphisms.
Shiokawa S, Fucharoen S, Fucharoen G, Tomatsu S, Fukumaki Y. J Biochem. 1989 Feb; 105(2):184-9.
Review Sequence polymorphisms of potential functional relevance in the beta-globin gene locus. [Hemoglobin. 1996]
Review Sequence polymorphisms of potential functional relevance in the beta-globin gene locus.
Labie D, Elion J. Hemoglobin. 1996 May; 20(2):85-101.
Review DNA haplotypes and the beta s globin gene. [Prog Clin Biol Res. 1989]
Review DNA haplotypes and the beta s globin gene.
Nagel RL, Labie D. Prog Clin Biol Res. 1989; 316B:371-93.

See reviews... See all...

Cited by 1 PubMed Central article

Homology requirements for unequal crossing over in humans. [Genetics. 1991]
Homology requirements for unequal crossing over in humans.
Metzenberg AB, Wurzer G, Huisman TH, Smithies O. Genetics. 1991 May; 128(1):143-61.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Genetic polymorphisms of gene conversion within the duplicated human alpha-globi...
Genetic polymorphisms of gene conversion within the duplicated human alpha-globin loci.
Hum Genet. 1990 May ;84(6):568-70.

PubMed
Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a b...
Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies.
Leuk Res. 2010 Feb ;34(2):210-20. Epub 2009 Aug 25 .

PubMed
HNF-1 shares three sequence motifs with the POU domain proteins and is identical...
HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.
Genes Dev. 1990 Mar ;4(3):372-9.

PubMed
The health and health system of South Africa: historical roots of current public...
The health and health system of South Africa: historical roots of current public health challenges.
Lancet. 2009 Sep 5 ;374(9692):817-34. Epub 2009 Aug 24 .

PubMed
Clonal and systemic analysis of long-term hematopoiesis in the mouse.
Clonal and systemic analysis of long-term hematopoiesis in the mouse.
Genes Dev. 1990 Feb ;4(2):220-32.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: