Format

Send to:

Choose Destination
See comment in PubMed Commons below
PLoS One. 2009 Aug 26;4(8):e6785. doi: 10.1371/journal.pone.0006785.

A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.

Author information

  • 1Department of Molecular Biology, Hadassah Medical School, The Hebrew University, Jerusalem, Israel.

Abstract

Toxin-antitoxin (TA) modules are gene pairs specifying for a toxin and its antitoxin and are found on the chromosomes of many bacteria including pathogens. Here we report how each of five such TA systems in E. coli affect bacterial cell death differently in liquid media and during biofilm formation. Of all these systems, only the TA system mazEF mediated cell death both in liquid media and during biofilm formation. At the other extreme, as our results have revealed here, the TA system dinJ-YafQ is unique in that it is involved only in the death process during biofilm formation. Cell death governed by mazEF and dinJ-YafQ seems to participate in biofilm formation through a novel mechanism.

PMID:
19707553
[PubMed - indexed for MEDLINE]
PMCID:
PMC2727947
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Public Library of Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk