Nat Rev Cardiol. 2009 Oct;6(10):632-8. Epub 2009 Aug 25.

Cardiovascular pharmacogenomics and individualized drug therapy.

Source

Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA. pereira.naveen@mayo.edu

Abstract

The goal of individualized drug therapy requires physicians to be able to accurately predict an individual's response to a drug. Both genetic and environmental factors are known to influence drug response. 'Pharmacogenetics' is the study of the role of inheritance in variation in drug response phenotypes. Pharmacogenetics is now moving genome-wide to become 'pharmacogenomics', resulting in the recognition of novel biomarkers for individual variation in drug response. This article reviews the development, promise and challenges facing pharmacogenomics, using examples of drugs used to treat or prevent cardiovascular disease.

PMID:: 19707183; [PubMed - indexed for MEDLINE]
PMCID:: PMC3108370

Free PMC Article

Images from this publication.See all images (3) Free text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Cardiovascular Agents

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Review Cardiovascular pharmacogenomics. [Circ Res. 2011]
Review Cardiovascular pharmacogenomics.
Roden DM, Johnson JA, Kimmel SE, Krauss RM, Medina MW, Shuldiner A, Wilke RA. Circ Res. 2011 Sep 16; 109(7):807-20.
Review Pharmacogenomics in cardiovascular disease: the role of single nucleotide polymorphisms in improving drug therapy. [Expert Opin Pharmacother. 2005]
Review Pharmacogenomics in cardiovascular disease: the role of single nucleotide polymorphisms in improving drug therapy.
Mango R, Vecchione L, Raso B, Borgiani P, Brunetti E, Mehta JL, Lauro R, Romeo F, Novelli G. Expert Opin Pharmacother. 2005 Dec; 6(15):2565-76.
Review Genomics and the prospects of existing and emerging therapeutics for cardiovascular diseases. [Curr Pharm Des. 2009]
Review Genomics and the prospects of existing and emerging therapeutics for cardiovascular diseases.
Zaiou M, Benachour H, Marteau JB, Visvikis-Siest S, Siest G. Curr Pharm Des. 2009; 15(27):3193-206.
Review Pharmacogenetics, pharmacogenomics, and cardiovascular therapeutics: the way forward. [Am J Cardiovasc Drugs. 2002]
Review Pharmacogenetics, pharmacogenomics, and cardiovascular therapeutics: the way forward.
Terra SG, Johnson JA. Am J Cardiovasc Drugs. 2002; 2(5):287-96.
Review Pharmacogenomics: a systems approach. [Wiley Interdiscip Rev Syst Bio...]
Review Pharmacogenomics: a systems approach.
Wang L. Wiley Interdiscip Rev Syst Biol Med. 2010 Jan-Feb; 2(1):3-22.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Ten questions about systems biology. [J Physiol. 2011]
Review Ten questions about systems biology.
Joyner MJ, Pedersen BK. J Physiol. 2011 Mar 1; 589(Pt 5):1017-30. Epub 2011 Jan 4.
Review Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. [Am J Respir Crit Care Med. 2010]
Review Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, et al. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1554-62. Epub 2010 Sep 10.
Review Genetics of atrial fibrillation: implications for future research directions and personalized medicine. [Circ Arrhythm Electrophysiol. ...]
Review Genetics of atrial fibrillation: implications for future research directions and personalized medicine.
Lubitz SA, Ozcan C, Magnani JW, Kääb S, Benjamin EJ, Ellinor PT. Circ Arrhythm Electrophysiol. 2010 Jun; 3(3):291-9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cardiovascular pharmacogenomics and individualized drug therapy.
Cardiovascular pharmacogenomics and individualized drug therapy.
Nat Rev Cardiol. 2009 Oct ;6(10):632-8. Epub 2009 Aug 25 .

PubMed
Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta...
Childhood atypical teratoid rhabdoid tumor of the central nervous system: a meta-analysis of observational studies.
J Pediatr Hematol Oncol. 2009 Sep ;31(9):651-63.

PubMed
The tools of an evidence-based culture: implementing clinical-practice guideline...
The tools of an evidence-based culture: implementing clinical-practice guidelines in an Israeli HMO.
Acad Med. 2009 Sep ;84(9):1217-25.

PubMed
Comparison of direct and indirect methods of carrier detection in an X-linked di...
Comparison of direct and indirect methods of carrier detection in an X-linked disease.
Am J Med Genet. 1990 Apr ;35(4):600-8.

PubMed
Indications and common surgical approaches for cochlear implantation in China.
Indications and common surgical approaches for cochlear implantation in China.
ORL J Otorhinolaryngol Relat Spec. 2009 ;71(4):187-91. Epub 2009 Aug 26 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: