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Hum Genomics. 2009 Jul;3(4):304-7.

Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4.

Author information

  • 1Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago. smmatrix2k1@yahoo.com

Abstract

This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.

PMID:
19706361
[PubMed - indexed for MEDLINE]
PMCID:
PMC2885287
Free PMC Article

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