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    Hum Genomics. 2009 Jul;3(4):304-7.

    Identification of a novel cytosolic aldehyde dehydrogenase allele, ALDH1A1*4.

    Moore SM, Liang T, Graves TJ, McCall KM, Carr LG, Ehlers CL.

    Source

    Pharmacology Unit, Department of Paraclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad and Tobago. smmatrix2k1@yahoo.com

    Abstract

    This paper reports the identification of a novel cytosolic aldehyde dehydrogenase 1 ( ALDH1A1 ) allele. One hundred and sixty-two Indo-Trinidadian and 85 Afro-Trinidadian individuals were genotyped. A novel ALDH1A1 allele, ALDH1A1*4 , was identified in an Indo-Trinidadian alcoholic with an A inserted at position -554 relative to the translational start site, +1. It was concluded that a wider cross-section of individuals needs to be evaluated in order to determine the representative frequency of the allele, and to see if it is associated with risk of alcoholism.

    PMID:
    19706361
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2885287
    Free PMC Article

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