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Aliment Pharmacol Ther. 2009 Oct 15;30(8):826-33. doi: 10.1111/j.1365-2036.2009.04102.x. Epub 2008 Jul 23.

Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii.

Author information

  • Division of Digestive Diseases, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA. cpothoulakis@mednet.ucla.edu

Abstract

BACKGROUND:

Saccharomyces boulardii, a well-studied probiotic, can be effective in inflammatory gastrointestinal diseases with diverse pathophysiology, such as inflammatory bowel disease (IBD), and bacterially mediated or enterotoxin-mediated diarrhoea and inflammation.

AIM:

To discuss the mechanisms of action involved in the intestinal anti-inflammatory action of S. boulardii.

METHODS:

Review of the literature related to the anti-inflammatory effects of this probiotic.

RESULTS:

Several mechanisms of action have been identified directed against the host and pathogenic microorganisms. S. boulardii and S. boulardii secreted-protein(s) inhibit production of proinflammatory cytokines by interfering with the global mediator of inflammation nuclear factor kappaB, and modulating the activity of the mitogen-activated protein kinases ERK1/2 and p38. S. boulardii activates expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) that protects from gut inflammation and IBD. S. boulardii also suppresses 'bacteria overgrowth' and host cell adherence, releases a protease that cleaves C. difficile toxin A and its intestinal receptor and stimulates antibody production against toxin A. Recent results indicate that S. boulardii may interfere with IBD pathogenesis by trapping T cells in mesenteric lymph nodes.

CONCLUSIONS:

The multiple anti-inflammatory mechanisms exerted by S. boulardii provide molecular explanations supporting its effectiveness in intestinal inflammatory states.

PMID:
19706150
[PubMed - indexed for MEDLINE]
PMCID:
PMC2761627
Free PMC Article
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