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Departamento de Farmacologia, Universidade de São Paulo, Brasil.
1. Studies on the mechanisms of FCF action using behavioural and biochemical methods have shown that all stimulant effects produced by acute administration of FCF are thought to be due to indirect activation of DA systems in CNS. 2. Changes in the sensitivity of pre- or postsynaptic DA receptors might underlie both tolerance and sensitization to the effects induced by long-term FCF administration.
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