Neurology. 1990 May;40(5):832-4.

Clozapine in the treatment of parkinsonian patients with dopaminomimetic psychosis.

Wolters EC, Hurwitz TA, Mak E, Teal P, Peppard FR, Remick R, Calne S, Calne DB.

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Department of Medicine, University Hospital, University of British Columbia, Vancouver, Canada.

Abstract

In a double-blind placebo-controlled study, we evaluated the effects of clozapine (75 to 250 mg/day, mean 170.8) on dopaminomimetic psychosis and parkinsonian disability. Clozapine prevented deterioration of psychosis during the increase of dopaminomimetics in the 3 patients who completed the study. Worsening of parkinsonism occurred in 3 of the 6 patients. In the dosage used, clozapine's usefulness was limited by its propensity to produce sedation, confusion, and increased parkinsonism.

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