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Antimicrob Agents Chemother. 2009 Nov;53(11):4907-10. doi: 10.1128/AAC.00345-09. Epub 2009 Aug 24.

Penetration of colistin into cerebrospinal fluid.

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  • 1Department of Pharmaceutical Technology, Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Athens, Panepistimiopolis, 157.71 Athens, Greece.


Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with the exception of one patient with an external ventriculostomy. CSF-to-serum ratios (0.051 to 0.057) for all study patients coincided at all sampling times. The low level (5%) of penetration suggests inadequate bactericidal colistin concentrations in the CSF.

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