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Antimicrob Agents Chemother. 2009 Nov;53(11):4907-10. doi: 10.1128/AAC.00345-09. Epub 2009 Aug 24.

Penetration of colistin into cerebrospinal fluid.

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  • 1Department of Pharmaceutical Technology, Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmacy, University of Athens, Panepistimiopolis, 157.71 Athens, Greece. kyroudi@pharm.uoa.gr

Abstract

Colistin penetration into the cerebrospinal fluid (CSF) was studied in five critically ill adult patients receiving colistin methanesulfonate for infections by multiresistant gram-negative bacilli. Colistin concentrations were determined in paired serum and CSF samples, with the latter taken by lumbar puncture, with the exception of one patient with an external ventriculostomy. CSF-to-serum ratios (0.051 to 0.057) for all study patients coincided at all sampling times. The low level (5%) of penetration suggests inadequate bactericidal colistin concentrations in the CSF.

PMID:
19704130
[PubMed - indexed for MEDLINE]
PMCID:
PMC2772309
Free PMC Article
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