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Cell. 2009 Aug 21;138(4):628-44. doi: 10.1016/j.cell.2009.08.005.

Importing mitochondrial proteins: machineries and mechanisms.

Author information

  • 1Institut für Biochemie und Molekularbiologie, ZBMZ, Universität Freiburg, 79104 Freiburg, Germany.

Abstract

Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor proteins. The translocases that catalyze these processes are highly dynamic machines driven by the membrane potential, ATP, or redox reactions, and they cooperate with molecular chaperones and assembly complexes to direct mitochondrial proteins to their correct destinations. Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis.

PMID:
19703392
[PubMed - indexed for MEDLINE]
PMCID:
PMC4099469
Free PMC Article

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