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Exp Dermatol. 2010 Aug;19(8):e293-5. doi: 10.1111/j.1600-0625.2009.00979.x.

Improved quality of optical coherence tomography imaging of basal cell carcinomas using speckle reduction.

Abstract

BACKGROUND:

Optical coherence tomography (OCT) is a possible imaging method for delineation of non-melanoma skin cancer. Speckle noise is the dominant noise contribution in OCT images; it limits the ability to identify cellular structures especially skin cancer. QUESTIONS ADDRESSED: This report suggests a method for improving OCT image quality for skin cancer imaging.

EXPERIMENTAL DESIGN:

OCT is an optical imaging method analogous to ultrasound. Two basal cell carcinomas (BCC) were imaged using an OCT speckle reduction technique (SR-OCT) based on repeated scanning by altering the distance between the probe and the surface of the skin.

RESULTS:

SR-OCT resulted in improved visualisation and more accurate thickness measurements in BCC lesions.

CONCLUSION:

This OCT speckle reduction method led to improved visualisation and better defined delineations in two BCC lesions. Thus, OCT was improved to a clinically relevant level when imaging BCC lesions.

PMID:
19702838
[PubMed - indexed for MEDLINE]
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