Biochem J. 1990 Apr 1;267(1):265-7.

Distribution of hepatic glutaminase activity and mRNA in perivenous and periportal rat hepatocytes.

Source

Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853.

Abstract

Perivenous and periportal hepatocytes were isolated by the digitonin/collagenase perfusion technique. The specific activity of phosphate-activated glutaminase was 2.33-fold higher in periportal cells than in perivenous cells. Similarly, the relative abundance of glutaminase mRNA was 2.6-fold higher in samples from periportal cells. The distribution of glutaminase activity and mRNA was compared with those for glutamine synthetase (predominantly perivenous) and phosphoenolpyruvate carboxykinase (predominantly periportal). The results suggest that phosphate-activated glutaminase is predominantly expressed in the periportal zone of the liver acinus.

PMID:: 1970242; [PubMed - indexed for MEDLINE]
PMCID:: PMC1131276

Free PMC Article

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Intrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long-term system for study of liver-specific gene expression. [Hepatology. 1994]
Intrasplenic transplantation of isolated periportal and perivenous hepatocytes as a long-term system for study of liver-specific gene expression.
Chen L, Davis GJ, Crabb DW, Lumeng L. Hepatology. 1994 Apr; 19(4):989-98.
Regulation of hepatic ammonia metabolism: the intercellular glutamine cycle. [Adv Enzyme Regul. 1986]
Regulation of hepatic ammonia metabolism: the intercellular glutamine cycle.
Häussinger D. Adv Enzyme Regul. 1986; 25:159-80.
Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion. [Hepatology. 1989]
Different capacities for amino acid transport in periportal and perivenous hepatocytes isolated by digitonin/collagenase perfusion.
Burger HJ, Gebhardt R, Mayer C, Mecke D. Hepatology. 1989 Jan; 9(1):22-8.
Review Hepatic glutamine metabolism. [Beitr Infusionther Klin Ernahr...]
Review Hepatic glutamine metabolism.
Häussinger D. Beitr Infusionther Klin Ernahr. 1987; 17:144-57.
Review Metabolic heterogeneity of hepatocytes across the liver acinus. [J Nutr. 1992]
Review Metabolic heterogeneity of hepatocytes across the liver acinus.
Katz NR. J Nutr. 1992 Mar; 122(3 Suppl):843-9.

See reviews... See all...

Cited by 10 PubMed Central articles

Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations. [J Biomed Sci. 2010]
Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations.
Comar JF, Suzuki-Kemmelmeier F, Constantin J, Bracht A. J Biomed Sci. 2010 Jan 7; 17:1. Epub 2010 Jan 7.
Co-expression of glutaminase K and L isoenzymes in human tumour cells. [Biochem J. 2005]
Co-expression of glutaminase K and L isoenzymes in human tumour cells.
Pérez-Gómez C, Campos-Sandoval JA, Alonso FJ, Segura JA, Manzanares E, Ruiz-Sánchez P, González ME, Márquez J, Matés JM. Biochem J. 2005 Mar 15; 386(Pt 3):535-42.
De novo expression of glutamine synthetase during transformation of hepatic stellate cells into myofibroblast-like cells. [Biochem J. 1998]
De novo expression of glutamine synthetase during transformation of hepatic stellate cells into myofibroblast-like cells.
Bode JG, Peters-Regehr T, Gressner AM, Häussinger D. Biochem J. 1998 Nov 1; 335 ( Pt 3):697-700.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Distribution of hepatic glutaminase activity and mRNA in perivenous and periport...
Distribution of hepatic glutaminase activity and mRNA in perivenous and periportal rat hepatocytes.
Biochem J. 1990 Apr 1 ;267(1):265-7.

PubMed
Selectivity of executive function deficits in mild cognitive impairment.
Selectivity of executive function deficits in mild cognitive impairment.
Neuropsychology. 2009 Sep ;23(5):607-18.

PubMed
Associations of postural knowledge and basic motor skill with dyspraxia in autis...
Associations of postural knowledge and basic motor skill with dyspraxia in autism: implication for abnormalities in distributed connectivity and motor learning.
Neuropsychology. 2009 Sep ;23(5):563-70.

PubMed
The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.
The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.
Annu Rev Neurosci. 1990 ;13:171-82.

PubMed
Evaluation of virtual screening as a tool for chemical genetic applications.
Evaluation of virtual screening as a tool for chemical genetic applications.
J Chem Inf Model. 2009 Sep ;49(9):2082-91.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Distribution of hepatic glutaminase activity and mRNA in perivenous and periportal rat hepatocytes.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 10 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information