Acta Psychiatr Scand. 1990 Feb;81(2):168-9.

Neuroleptic malignant syndrome during abrupt reduction of neuroleptic treatment.

Spivak B, Weizman A, Wolovick L, Hermesh H, Tyano S, Munitz H.

Source

Gehah Psychiatric Hospital, Beilinson Medical Center, Petah Tiqva, Israel.

Abstract

Development of neuroleptic malignant syndrome (NMS) following discontinuation of high-dose and high-potency neuroleptic agents is described. This case, although rare and atypical, should alert clinicians to consider the possibility of NMS as a complication of abrupt neuroleptic drug withdrawal. It is suggested that dopaminergic imbalance, as opposed to excessive dopaminergic blockade, may also play a role in the precipitation of NMS.

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