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Clin Chest Med. 2009 Sep;30(3):489-93, viii. doi: 10.1016/j.ccm.2009.05.006.

Obesity and thromboembolic disease.

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  • 1Department of Research, St. Joseph Mercy Oakland Hospital, Pontiac, MI 48341-5023, USA.


Various abnormalities of hemostasis have been described in obesity, mainly concerning increased levels of plasminogen activator inhibitor-1, but other abnormalities of coagulation and platelet activation have been reported as well. Circulating microparticles have also been observed in obese patients. These suggest that obesity would be a risk factor for venous thromboembolism (VTE). Analysis of the database of the National Hospital Discharge Survey showed compelling evidence that obesity is, in fact, a risk factor for VTE. Obesity is also a risk factor for recurrent VTE. A synergistic effect of oral contraceptives with obesity has been shown.

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