Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Immunol. 2009 Nov;30(11):513-21. doi: 10.1016/j.it.2009.07.011. Epub 2009 Aug 21.

NETs: a new strategy for using old weapons.

Author information

  • 1Department for Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany. veni@mpiib-berlin.mpg.de

Abstract

As key players in the host innate immune response, neutrophils are recruited to sites of infection and constitute the first line of defense. They employ three strategies to eliminate invading microbes: microbial uptake, the secretion of antimicrobials, and the recently described release of Neutrophil Extracellular Traps (NETs). Composed of decondensed chromatin and antimicrobial proteins, NETs bind and kill a variety of microbes including bacteria, fungi, and parasites. In addition to using a repertoire of known antimicrobials, NETs incorporate histones into the antimicrobial arsenal. Furthermore, NETs may contribute to microbial containment by forming a physical barrier and a scaffold, to enhance antimicrobial synergy while minimizing damage to host tissues. Their role in innate immunity is only now being uncovered.

PMID:
19699684
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk