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Immunity. 2009 Aug 21;31(2):178-80. doi: 10.1016/j.immuni.2009.08.005.

Blimp hovers over T cell immunity.

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  • 1Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.


The functions of T lymphocytes are regulated by transcription factors controlling gene expression. Three studies in this issue of Immunity (Kallies et al., 2009; Rutishauser et al., 2009; Shin et al., 2009) indicate that the transcriptional repressor Blimp-1 promotes the development of short-lived effector cells and regulates clonal exhaustion.

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