Immunity. 2009 Aug 21;31(2):178-80.

Blimp hovers over T cell immunity.

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Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA. raymond.welsh@umassmed.edu

Abstract

The functions of T lymphocytes are regulated by transcription factors controlling gene expression. Three studies in this issue of Immunity (Kallies et al., 2009; Rutishauser et al., 2009; Shin et al., 2009) indicate that the transcriptional repressor Blimp-1 promotes the development of short-lived effector cells and regulates clonal exhaustion.

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A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. [Immunity. 2009]
A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.
Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ. Immunity. 2009 Aug 21; 31(2):309-20. Epub 2009 Aug 6.
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. [Immunity. 2009]
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.
Rutishauser RL, Martins GA, Kalachikov S, Chandele A, Parish IA, Meffre E, Jacob J, Calame K, Kaech SM. Immunity. 2009 Aug 21; 31(2):296-308. Epub 2009 Aug 6.
CD8 T cell responses to lymphocytic choriomeningitis virus in early growth response gene 1-deficient mice. [J Immunol. 2004]
CD8 T cell responses to lymphocytic choriomeningitis virus in early growth response gene 1-deficient mice.
Singh A, Svaren J, Grayson J, Suresh M. J Immunol. 2004 Sep 15; 173(6):3855-62.
Review Blimp1: driving terminal differentiation to a T. [Adv Exp Med Biol. 2011]
Review Blimp1: driving terminal differentiation to a T.
Xin A, Nutt SL, Belz GT, Kallies A. Adv Exp Med Biol. 2011; 780:85-100.
Review Transcription factor regulation of CD8+ T-cell memory and exhaustion. [Immunol Rev. 2010]
Review Transcription factor regulation of CD8+ T-cell memory and exhaustion.
Angelosanto JM, Wherry EJ. Immunol Rev. 2010 Jul; 236:167-75.

See reviews... See all...

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Heterogeneity within T Cell Memory: Implications for Transplant Tolerance. [Front Immunol. 2012]
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance.
Krummey SM, Ford ML. Front Immunol. 2012; 3:36. Epub 2012 Mar 1.
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Lucas CL, Workman CJ, Beyaz S, LoCascio S, Zhao G, Vignali DA, Sykes M. Blood. 2011 May 19; 117(20):5532-40. Epub 2011 Mar 21.

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