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Adv Virus Res. 2009;74:103-21. doi: 10.1016/S0065-3527(09)74003-5.

Chapter 3. Replication of the hepatitis delta virus RNA genome.

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  • 1Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.


Hepatitis delta virus (HDV) is a subviral agent dependent upon hepatitis B virus (HBV). HDV uses the envelope proteins of HBV to achieve assembly and infection of target cells. Otherwise, the replication of the RNA genome of HDV is totally different from that of its helper virus, and involves redirection of host polymerase activity. This chapter is concerned with recent developments in our understanding of the genome replication process.

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