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Genome Biol. 2009;10(8):R86. doi: 10.1186/gb-2009-10-8-r86. Epub 2009 Aug 21.

Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes.

Author information

  • 1Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway. xianjun.dong@bccs.uib.no

Abstract

Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes, often immobilizing other, unrelated genes into long-lasting syntenic arrangements. Synorth http://synorth.genereg.net/ is a web resource for exploring and categorizing the syntenic relationships in genomic regulatory blocks across multiple genomes, tracing their evolutionary fate after teleost whole genome duplication at the level of genomic regulatory block loci, individual genes, and their phylogenetic context.

PMID:
19698106
[PubMed - indexed for MEDLINE]
PMCID:
PMC2745767
Free PMC Article

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