Format

Send to:

Choose Destination
See comment in PubMed Commons below
Tissue Eng Part B Rev. 2010 Apr;16(2):169-87. doi: 10.1089/ten.TEB.2009.0352.

Challenges in cardiac tissue engineering.

Author information

  • 1Department of Biomedical Engineering, Columbia University, New York, New York 10032, USA.

Abstract

Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of the cell-the actual "tissue engineer"-is mobilized by providing highly controllable three-dimensional environments that can mediate cell differentiation and functional assembly. For cardiac regeneration, some of the key requirements that need to be met are the selection of a human cell source, establishment of cardiac tissue matrix, electromechanical cell coupling, robust and stable contractile function, and functional vascularization. We review here the potential and challenges of cardiac tissue engineering for developing therapies that could prevent or reverse heart failure.

PMID:
19698068
[PubMed - indexed for MEDLINE]
PMCID:
PMC2946883
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Write to the Help Desk