Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Rev Mol Cell Biol. 2009 Sep;10(9):609-22. doi: 10.1038/nrm2748.

Endocytosis and signalling: intertwining molecular networks.

Author information

  • 1Department of Pharmacology, University of Colorado Denver School of Medicine, Aurora, 80010, USA. alexander.sorkin@ucdenver.edu

Abstract

Cell signalling and endocytic membrane trafficking have traditionally been viewed as distinct processes. Although our present understanding is incomplete and there are still great controversies, it is now recognized that these processes are intimately and bidirectionally linked in animal cells. Indeed, many recent examples illustrate how endocytosis regulates receptor signalling (including signalling from receptor tyrosine kinases and G protein-coupled receptors) and, conversely, how signalling regulates the endocytic pathway. The mechanistic and functional principles that underlie the relationship between signalling and endocytosis in cell biology are becoming increasingly evident across many systems.

PMID:
19696798
[PubMed - indexed for MEDLINE]
PMCID:
PMC2895425
Free PMC Article

Images from this publication.See all images (5)Free text

Figure 1
Figure 2
Figure 3
Box 1
Box 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk