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J Med Chem. 2009 Sep 24;52(18):5748-52. doi: 10.1021/jm9009668.

Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.

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  • 1Department of Pharmacology and Department of Medicine, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA.

Abstract

Resistance to chemotherapy and endocrine therapy is a major cause of breast cancer treatment failure. We have synthesized six novel analogues using C8-ceramide as the lead analogue and studied their effect on hormone therapy resistant (MDA-MB-231) and chemoresistant (MCF-7TN-R) breast cancer cells. Pharmacologic intervention using these ceramide analogues inhibited clonogenic survival and induced apoptosis, with one analogue being more effective than C8-ceramide. Our results show ceramide-based therapy has therapeutic potential in treating drug resistant breast cancer.

PMID:
19694470
[PubMed - indexed for MEDLINE]
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