Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Jul;38(4):415-21.

[Transforming growth factor-beta and its receptors in scleroderma].

[Article in Chinese]

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Department of Dermatology and Venereology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.

Abstract

The hallmark of scleroderma is fibrosis by excessive extracellular matrix (ECM) deposition in the skin, lung, and other organs. Increasing evidence suggests that overexpression of transforming growth factor-beta (TGF-beta) and its receptors play a key pathogenic role in the development of tissue fibrosis in scleroderma. TGF-beta is known to induce the expression of ECM proteins in the pathogenesis of fibrosis in systemic sclerosis. Investigations into TGF-beta pathways will suggest new treatment strategies for fibrotic diseases.

PMID:: 19693982; [PubMed - indexed for MEDLINE]

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