Nat Rev Neurosci. 2009 Sep;10(9):627-34.

WNTs tune up the neuromuscular junction.

Source

Department of Neurobiology, Aaron Lazare Biomedical Research Building, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Abstract

Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction in nematodes, insects, fish and mammals. These studies place WNTs as major determinants of synapse differentiation and neurotransmitter receptor clustering.

PMID:: 19693027; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Wnt Proteins

Grant Support

MH70000/MH/NIMH NIH HHS/United States

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Review Wnts: up-and-coming at the synapse. [Trends Neurosci. 2007]
Review Wnts: up-and-coming at the synapse.
Speese SD, Budnik V. Trends Neurosci. 2007 Jun; 30(6):268-75. Epub 2007 Apr 27.
Review Synaptic plasticity: keeping synapses under control. [Curr Biol. 1998]
Review Synaptic plasticity: keeping synapses under control.
Landmesser LT. Curr Biol. 1998 Jul 30-Aug 13; 8(16):R564-7.
Review Modulation of neurotransmission by reciprocal synapse-glial interactions at the neuromuscular junction. [J Neurocytol. 2003]
Review Modulation of neurotransmission by reciprocal synapse-glial interactions at the neuromuscular junction.
Auld DS, Colomar A, Bélair EL, Castonguay A, Pinard A, Rousse I, Thomas S, Robitaille R. J Neurocytol. 2003 Jun-Sep; 32(5-8):1003-15.
Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling. [Neuron. 2008]
Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling.
Ataman B, Ashley J, Gorczyca M, Ramachandran P, Fouquet W, Sigrist SJ, Budnik V. Neuron. 2008 Mar 13; 57(5):705-18.
Review Activity-dependent synaptic plasticity: insights from neuromuscular junctions. [Neuroscientist. 2002]
Review Activity-dependent synaptic plasticity: insights from neuromuscular junctions.
Personius KE, Balice-Gordon RJ. Neuroscientist. 2002 Oct; 8(5):414-22.

See reviews... See all...

Cited by 6 PubMed Central articles

Wnt4 participates in the formation of vertebrate neuromuscular junction. [PLoS One. 2012]
Wnt4 participates in the formation of vertebrate neuromuscular junction.
Strochlic L, Falk J, Goillot E, Sigoillot S, Bourgeois F, Delers P, Rouvière J, Swain A, Castellani V, Schaeffer L, et al. PLoS One. 2012; 7(1):e29976. Epub 2012 Jan 12.
From synapse to nucleus and back again--communication over distance within neurons. [J Neurosci. 2011]
From synapse to nucleus and back again--communication over distance within neurons.
Fainzilber M, Budnik V, Segal RA, Kreutz MR. J Neurosci. 2011 Nov 9; 31(45):16045-8.
Review En1 and Wnt signaling in midbrain dopaminergic neuronal development. [Neural Dev. 2011]
Review En1 and Wnt signaling in midbrain dopaminergic neuronal development.
Alves dos Santos MT, Smidt MP. Neural Dev. 2011 May 10; 6:23. Epub 2011 May 10.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

WNTs tune up the neuromuscular junction.
WNTs tune up the neuromuscular junction.
Nat Rev Neurosci. 2009 Sep ;10(9):627-34.

PubMed
Coordination of Rho GTPase activities during cell protrusion.
Coordination of Rho GTPase activities during cell protrusion.
Nature. 2009 Sep 3 ;461(7260):99-103. Epub 2009 Aug 19 .

PubMed
Association of CYP2B6, CYP3A5, and CYP2C19 genetic polymorphisms with sibutramin...
Association of CYP2B6, CYP3A5, and CYP2C19 genetic polymorphisms with sibutramine pharmacokinetics in healthy Korean subjects.
Clin Pharmacol Ther. 2009 Nov ;86(5):511-8. Epub 2009 Aug 19 .

PubMed
Preliminary evidence for the effects of morphine on posttraumatic stress disorde...
Preliminary evidence for the effects of morphine on posttraumatic stress disorder symptoms in one- to four-year-olds with burns.
J Burn Care Res. 2009 Sep-Oct ;30(5):836-43.

PubMed
Noninvasive measurement of edema in partial thickness burn wounds.
Noninvasive measurement of edema in partial thickness burn wounds.
J Burn Care Res. 2009 Sep-Oct ;30(5):807-17.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: