Am J Hum Genet. 1990 Apr;46(4):789-94.

The ataxia-telangiectasia gene (ATA) on chromosome II is distinct from the ETS-1 gene.

Concannon P, Malhotra U, Charmley P, Reynolds J, Lange K, Gatti RA.

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Virginia Mason Research Center, Seattle, WA 98101.

Abstract

We have studied the segregation of an RFLP detected with a human ETS-1 genomic probe in 25 families containing members affected with ataxia-telangiectasia (AT) and in 27 families from the Centre d'Etude du Polymorphisme Humain (CEPH) panel. We have recently mapped a gene for AT to 11q22-23 by linkage to the markers THY1 and D11S144. Multipoint linkage analysis of the CEPH families indicated that ETS-1 is located on chromosome 11q approximately 19.2 centimorgans telomeric to THY1. Analysis of the segregation of ETS-1 alleles in AT families yields strongly negative LOD scores, excluding an AT gene from a region extending 15 cM to either side of ETS-1. Multipoint mapping of ETS-1, D11S144, THY1, and AT also excludes the possibility that an AT gene is telomeric to ETS-1.

PMID:: 1969227; [PubMed - indexed for MEDLINE]
PMCID:: PMC1683674

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Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region. [Am J Hum Genet. 1990]
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Cited by 2 PubMed Central articles

Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region. [Am J Hum Genet. 1990]
Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.
Sanal O, Wei S, Foroud T, Malhotra U, Concannon P, Charmley P, Salser W, Lange K, Gatti RA. Am J Hum Genet. 1990 Nov; 47(5):860-6.
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium. [Am J Hum Genet. 1991]
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
Foroud T, Wei S, Ziv Y, Sobel E, Lange E, Chao A, Goradia T, Huo Y, Tolun A, Chessa L, et al. Am J Hum Genet. 1991 Dec; 49(6):1263-79.

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