Lancet. 1990 Mar 24;335(8691):701-3.

Alpha-ketoglutarate and postoperative muscle catabolism.

Source

Department of Anaesthesiology and Intensive Care, St Göran's Hospital, Karolinska Institute, Stockholm, Sweden.

Abstract

The hypothesis that muscle protein catabolism after trauma is associated with a shortage of alpha-ketoglutarate, rather than glutamine, was tested. Addition of alpha-ketoglutarate to postoperative total parenteral nutrition prevented the decrease in muscle protein synthesis and free glutamine that usually occurs after surgery. alpha-ketoglutarate supplementation may improve recovery after trauma.

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Alpha-ketoglutarate and postoperative muscle catabolism.

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