Lancet. 1990 Mar 17;335(8690):619-21.

Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection.

Source

Department of Child Health, Institute of Child Health, London, UK.

Abstract

To assess methyl-group metabolism in the central nervous system in infection with human immunodeficiency virus (HIV), levels of 5-methyltetrahydrofolate, methionine, and S-adenosylmethionine were measured by high-performance liquid chromatography in cerebrospinal fluid (CSF) from six children with congenital HIV infection and neurological complications. Total neopterins were also measured, as a marker of macrophage activation. In all six children concentrations of one or more methyl-group carriers were lower than those in a reference population of children, and all of the five in whom CSF neopterins were measured had higher than normal levels. Defective methylation may play a part in the neurological damage caused by HIV infection.

Comment in

Lancet. 1990 May 12;335(8698):1167.

PMID:: 1969014; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Cerebrospinal fluid concentrations of S-adenosylmethionine, methionine, and 5-methyltetrahydrofolate in a reference population: cerebrospinal fluid S-adenosylmethionine declines with age in humans. [Biochem Med Metab Biol. 1990]
Cerebrospinal fluid concentrations of S-adenosylmethionine, methionine, and 5-methyltetrahydrofolate in a reference population: cerebrospinal fluid S-adenosylmethionine declines with age in humans.
Surtees R, Hyland K. Biochem Med Metab Biol. 1990 Oct; 44(2):192-9.
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans. [J Neurol Neurosurg Psychiatry....]
L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans.
Surtees R, Hyland K. J Neurol Neurosurg Psychiatry. 1990 Jul; 53(7):569-72.
Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients. [Lancet. 1991]
Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients.
Keating JN, Trimble KC, Mulcahy F, Scott JM, Weir DG. Lancet. 1991 Apr 20; 337(8747):935-9.
Review Neopterin and human immunodeficiency virus infection. [Eur J Clin Chem Clin Biochem. ...]
Review Neopterin and human immunodeficiency virus infection.
Hofmann B. Eur J Clin Chem Clin Biochem. 1993 Apr; 31(4):191-5.
Review Central nervous system pathology in pediatric AIDS. [Ann N Y Acad Sci. 1993]
Review Central nervous system pathology in pediatric AIDS.
Dickson DW, Llena JF, Nelson SJ, Weidenheim KM. Ann N Y Acad Sci. 1993 Oct 29; 693:93-106.

See reviews... See all...

Cited by 4 PubMed Central articles

Review Hypothesis on the pathogenesis of vacuolar myelopathy, dementia, and peripheral neuropathy in AIDS. [J Neurol Neurosurg Psychiatry....]
Review Hypothesis on the pathogenesis of vacuolar myelopathy, dementia, and peripheral neuropathy in AIDS.
Tan SV, Guiloff RJ. J Neurol Neurosurg Psychiatry. 1998 Jul; 65(1):23-8.
Review The pathogenesis of the neurological complications of HIV-1 infection. [Genitourin Med. 1993]
Review The pathogenesis of the neurological complications of HIV-1 infection.
Brew BJ. Genitourin Med. 1993 Oct; 69(5):333-40.
Folate deficiency in cerebrospinal fluid associated with a defect in folate binding protein in the central nervous system. [J Neurol Neurosurg Psychiatry....]
Folate deficiency in cerebrospinal fluid associated with a defect in folate binding protein in the central nervous system.
Wevers RA, Hansen SI, van Hellenberg Hubar JL, Holm J, Høier-Madsen M, Jongen PJ. J Neurol Neurosurg Psychiatry. 1994 Feb; 57(2):223-6.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Central-nervous-system methyl-group metabolism in children with neurological com...
Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection.
Lancet. 1990 Mar 17 ;335(8690):619-21.

PubMed
Distinct concentration-dependent effects of the polo-like kinase 1-specific inhi...
Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis.
Cancer Res. 2009 Sep 1 ;69(17):6969-77. Epub 2009 Aug 18 .

PubMed
Association of white blood cell count and peripheral arterial disease in patient...
Association of white blood cell count and peripheral arterial disease in patients with and without traditional risk factors.
Angiology. 2010 May ;61(4):382-7. Epub 2009 Aug 18 .

PubMed
Exercise-induced ventricular arrhythmias and risk of sudden cardiac death in pat...
Exercise-induced ventricular arrhythmias and risk of sudden cardiac death in patients with hypertrophic cardiomyopathy.
Eur Heart J. 2009 Nov ;30(21):2599-605. Epub 2009 Aug 17 .

PubMed
Pulse oximetry: technology to reduce child mortality in developing countries.
Pulse oximetry: technology to reduce child mortality in developing countries.
Ann Trop Paediatr. 2009 Sep ;29(3):165-75.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Central-nervous-system methyl-group metabolism in children with neurological complications of HIV infection.

Source

Abstract

Comment in

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information