Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, 53100 Siena, Italy. gennari@unisi.it
Paget's disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder.