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Opt Express. 2009 Aug 17;17(17):15342-9.

Nanodoublers as deep imaging markers for multi-photon microscopy.

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  • 1Université de Genève, GAP-Biophotonics, 20 rue de l'Ecole de Médecine, 1211 Geneva, Switzerland.


We demonstrate the possibility to excite second-harmonic (SH) active Fe(IO(3))(3) nanocrystals with two distinct laser sources at 800 and 1550 nm, and we show, by a complementary experimental and numerical study, how the wavelength flexibility inherent to non-phase-matched SH nanoparticles can be efficiently exploited to increase imaging penetration depth of markers embedded in biological samples.

(c) 2009 Optical Society of America

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