Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Opt Express. 2009 Aug 17;17(17):14534-42.

Fourier transform-second-harmonic generation imaging of biological tissues.

Author information

  • 1Photonics Research of Bio/nano Environments (PROBE), Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, 1406 W Green St, Urbana, IL 61801, USA.


Fourier transform-second-harmonic generation imaging is employed to obtain quantitative metrics of collagen fibers in biological tissues. In particular, the preferred orientation and maximum spatial frequency of collagen fibers for selected regions of interest in porcine trachea, ear, and cornea are determined. These metrics remain consistent when applied to collagen fibers in the ear, which can be expected from observation. Collagen fibers in the trachea are more random with large standard deviations in orientation, and large variations in maximum spatial frequency. In addition, these metrics are used to investigate structural changes through a 3D stack of the cornea. This technique can be used as a quantitative marker to assess the structure of collagen fibers that may change due to damage from disease or physical injury.

(c) 2009 Optical Society of America

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Optical Society of America
    Loading ...
    Write to the Help Desk