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FEBS Lett. 2009 Sep 17;583(18):3027-32. doi: 10.1016/j.febslet.2009.08.012. Epub 2009 Aug 15.

Lumcorin: a leucine-rich repeat 9-derived peptide from human lumican inhibiting melanoma cell migration.

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  • 1Laboratoire de Biochimie Médicale et de Biologie Moléculaire, CNRS UMR 6237, Université Reims-Champagne-Ardenne, F-51095 Reims, France.

Abstract

We previously showed that lumican decreases melanoma progression. The aim of the present study was to determine the active sequence of the lumican core protein responsible for the inhibition of melanoma cell migration. Using different recombinant and synthetic peptides derived from lumican, we localized an active site in the leucine-rich repeat 9 domain of the lumican core protein. We propose the name lumcorin (fragment of lumican core protein) for the active peptide derived from this site. Lumcorin was able to inhibit melanoma cell migration in vitro.

PMID:
19686741
[PubMed - indexed for MEDLINE]
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