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    Int J Clin Exp Med. 2009 Jun 15;2(2):159-75.

    Vitamin D Receptor Genetic Polymorphisms and Prostate Cancer Risk: A Meta-analysis of 36 Published Studies.

    Yin M, Wei S, Wei Q.

    Source

    Departments of Epidemiology, The University of Texas, M. D. Anderson Cancer Center 1515 Holcombe Blvd, Houston, TX77030, USA.

    Abstract

    To update data on the role of vitamin D receptor (VDR) single nucleotide polymorphisms (SNPs) in susceptibility to prostate cancer, we performed a meta-analysis of 36 eligible publications on the association of Taql, Apal, Bsml, Fokl and CDX2 SNPs of the VDR gene with prostate cancer risk. Our study suggested that the Taql t and Bsml B alleles were associated with reduced prostate cancer risk among all study populations. Stratified analysis by ethnicity revealed that the Apal a allele was associated with reduced prostate cancer risk only among Asian populations, whereas the Fokl f allele showed a trend of increased prostate cancer risk only among Caucasian populations in a dominant model, independent of tumor stage (local or advanced). These results suggest that VDR polymorphisms may be potential biomarkers for prostate cancer susceptibility.

    PMID:
    19684888
    [PubMed]
    PMCID:
    PMC2719705
    Free PMC Article

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