Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis

Nat Med. 2009 Sep;15(9):1013-5. doi: 10.1038/nm.1995. Epub 2009 Aug 16.

Abstract

T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.

MeSH terms

  • Animals
  • Case-Control Studies
  • Cell Proliferation / drug effects
  • Disease Models, Animal
  • Humans
  • Hyperplasia
  • Interleukins / antagonists & inhibitors
  • Interleukins / genetics
  • Interleukins / pharmacology
  • Interleukins / physiology*
  • Keratinocytes / drug effects
  • Keratinocytes / immunology
  • Keratinocytes / pathology
  • Keratinocytes / transplantation
  • Mice
  • Psoriasis / genetics
  • Psoriasis / immunology*
  • Psoriasis / pathology
  • Psoriasis / therapy
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Recombinant Proteins / pharmacology
  • T-Lymphocytes / immunology
  • Transplantation, Heterologous

Substances

  • Interleukins
  • RNA, Messenger
  • Recombinant Proteins
  • interleukin-21