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J Am Geriatr Soc. 2009 Oct;57(10):1874-80. doi: 10.1111/j.1532-5415.2009.02438.x. Epub 2009 Aug 13.

Plasma carboxymethyl-lysine, an advanced glycation end product, and all-cause and cardiovascular disease mortality in older community-dwelling adults.

Author information

  • 1Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. rdsemba@jhmi.edu

Abstract

OBJECTIVES:

To determine whether older adults with high plasma carboxymethyl-lysine (CML), an advanced glycation end product, are at higher risk of all-cause and cardiovascular disease (CVD) mortality.

DESIGN:

Prospective cohort study.

SETTING:

Population-based sample of adults aged 65 and older residing in Tuscany, Italy.

PARTICIPANTS:

One thousand thirteen adults participating in the Invecchiare in Chianti study.

MEASUREMENTS:

Anthropometric measures, plasma CML, fasting plasma total, high-density and low-density lipoprotein cholesterol, triglycerides, glucose, creatinine. Clinical measures: medical assessment, diabetes mellitus, hypertension, coronary heart disease, heart failure, stroke, cancer. Vital status measures: death certificates and causes of death according to the International Classification of Diseases. Survival methods were used to examine the relationship between plasma CML and all-cause and CVD mortality, adjusting for potential confounders.

RESULTS:

During 6 years of follow-up, 227 (22.4%) adults died, of whom 105 died with CVD. Adults with plasma CML in the highest tertile had greater all-cause (hazard ratio (HR)=1.84, 95% confidence interval) CI)=1.30-2.60, P<.001) and CVD (HR=2.11, 95% CI=1.27-3.49, P=.003) mortality than those in the lower two tertiles after adjusting for potential confounders. In adults without diabetes mellitus, those with plasma CML in the highest tertile had greater all-cause (HR=1.68, 95% CI=1.15-2.44, P=.006) and CVD (HR=1.74, 95% CI=1.00-3.01, P=.05) mortality than those in the lower two tertiles after adjusting for potential confounders.

CONCLUSION:

Older adults with high plasma CML are at higher risk of all-cause and CVD mortality.

PMID:
19682127
[PubMed - indexed for MEDLINE]
PMCID:
PMC2785105
Free PMC Article
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