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J Am Geriatr Soc. 2009 Sep;57(9):1580-6. doi: 10.1111/j.1532-5415.2009.02402.x. Epub 2009 Aug 4.

Effect of influenza vaccination of nursing home staff on mortality of residents: a cluster-randomized trial.

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  • 1Department of Epidemiology, Information Systems, and Modeling, University Pierre and Marie Curie Paris 6, UMR-S 707, Paris, France.

Abstract

OBJECTIVES:

To evaluate the effect of staff influenza vaccination on all-cause mortality in nursing home residents.

DESIGN:

Pair-matched cluster-randomized trial.

SETTING:

Forty nursing homes matched for size, staff vaccination coverage during the previous season, and resident disability index.

PARTICIPANTS:

All persons aged 60 and older residing in the nursing homes.

INTERVENTION:

Influenza vaccine was administered to volunteer staff after a face-to-face interview. No intervention took place in control nursing homes.

MEASUREMENTS:

The primary endpoint was total mortality rate in residents from 2 weeks before to 2 weeks after the influenza epidemic in the community. Secondary endpoints were rates of hospitalization and influenza-like illness (ILI) in residents and sick leave from work in staff.

RESULTS:

Staff influenza vaccination rates were 69.9% in the vaccination arm versus 31.8% in the control arm. Primary unadjusted analysis did not show significantly lower mortality in residents in the vaccination arm (odds ratio=0.86, P=.08), although multivariate-adjusted analysis showed 20% lower mortality (P=.02), and a strong correlation was observed between staff vaccination coverage and all-cause mortality in residents (correlation coefficient=-0.42, P=.007). In the vaccination arm, significantly lower resident hospitalization rates were not observed, but ILI in residents was 31% lower (P=.007), and sick leave from work in staff was 42% lower (P=.03).

CONCLUSION:

These results support influenza vaccination of staff caring for institutionalized elderly people.

PMID:
19682118
[PubMed - indexed for MEDLINE]
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