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    Cell. 1990 Feb 23;60(4):547-55.

    A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

    Kamps MP, Murre C, Sun XH, Baltimore D.

    Source

    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142.

    Abstract

    It was previously shown that the chromosome 19 breakpoint of the t(1;19)(q23;p13.3) translocation, found in human pre-B cell acute lymphoblastic leukemias, is within the E2A transcription factor gene on chromosome 19. A cell line with this translocation contains two novel chimeric mRNAs, both with the same 5'E2A sequences but with different lengths of 3' sequence from a previously unrecognized gene dubbed prl, located on chromosome 1. The chimeric RNAs encode a protein that lacks 171 amino acids of E2A, including its DNA binding and dimerization motifs, but have instead a homeobox-related sequence from prl. Therefore, the production of a chimeric E2A-Prl protein may contribute to the acute lymphoblastic phenotype by directly altering the expression of genes normally responsive to the Prl homeoprotein.

    PMID:
    1967983
    [PubMed - indexed for MEDLINE]

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