Leuk Res. 2010 Feb;34(2):173-6. Epub 2009 Aug 12.

Circulating Ki-67 protein in plasma as a biomarker and prognostic indicator of acute lymphoblastic leukemia.

Bruey JM, Kantarjian H, Estrov Z, Zhang Z, Ma W, Albitar F, Abdool A, Thomas D, Yeh C, O'Brien S, Albitar M.

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Hematology, Quest Diagnostics Nichols Institute, Building A, Hematopathology/Oncology R&D, 33608 Ortega Highway, San Juan Capistrano, CA 92675, United States. jeanmarie.x.bruey@questdiagnostics.com

Abstract

Tissue-based determination of Ki-67, a marker of cellular proliferation, has shown prognostic value in solid tumors and hematological malignancies. We developed and validated an electrochemiluminescence-based method for sensitive measurement of circulating Ki-67 in plasma (cKi-67). This assay demonstrated significantly higher levels of cKi-67 in patients with newly diagnosed acute lymphoblastic leukemia (ALL) (n=27; median, 762; range, 0-4574U/100 microL) than in healthy control subjects (n=114; median, 399; range, 36-2830U/100 microL). Moreover, elevated plasma cKi-67 was associated with significantly shorter survival in ALL patients (P=0.05). These findings suggest that Ki-67 can be detected in circulation and has potential for use as a biomarker for predicting clinical behavior in ALL.

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Leuk Res. 2010 Jul;34(7):848-9.

PMID:: 19679351; [PubMed - indexed for MEDLINE]

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