Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2010 Feb;1804(2):362-73. doi: 10.1016/j.bbapap.2009.08.002. Epub 2009 Aug 11.

Structure and catalytic mechanism of the beta-carbonic anhydrases.

Author information

  • 1Colgate University, Department of Chemistry, Hamilton, NY 13346, USA. rrowlett@colgate.edu

Abstract

The beta-carbonic anhydrases (beta-CAs) are a diverse but structurally related group of zinc-metalloenzymes found in eubacteria, plant chloroplasts, red and green algae, and in the Archaea. The enzyme catalyzes the rapid interconversion of CO(2) and H(2)O to HCO(3)(-) and H(+), and is believed to be associated with metabolic enzymes that consume or produce CO(2) or HCO(3)(-). For many organisms, beta-CA is essential for growth at atmospheric concentrations of CO(2). Of the five evolutionarily distinct classes of carbonic anhydrase, beta-CA is the only one known to exhibit allosterism. Here we review the structure and catalytic mechanism of beta-CA, including the structural basis for allosteric regulation.

Copyright 2009 Elsevier B.V. All rights reserved.

PMID:
19679201
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk